COPD and its co-morbidities

COPD is one of the world’s leading cause of death with prevalence ranging from 6% to 19% globally. This disease is particularly relevant for us in Asia-Pacific as risk factors such as smoking, biomass fuels, TB and air pollution are more prevalent than other regions. For example COPD prevalence in Chinese males is estimated to […]

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Intensive blood pressure lowering reduces heart attacks

One quarter of the world’s adult population suffers from hypertension, and although it has no obvious symptoms, it can lead to heart attacks, stroke, kidney failure and blindness. Despite this, there has been great uncertainty as to how intensively blood pressure should be lowered to obtain maximal benefit and minimize risks. Researchers from Australia, China, […]

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Benefits of DPPIV-inhibitors still uncertain

The recent SAVOR-TIMI 53 (saxagliptin) and EXAMINE (alogliptin) trials recently reported the effects of the DPPIV inhibitor class of glucose lowering agents in people with diabetes. As required by the US FDA, both drugs were found not to increase cardiovascular risk, allowing the agents to be registered for use in that country. Good news, it would […]

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Too busy for a healthy lifestyle?

As active contributors in research, sometimes it’s nice to take a step back and reflect how our work evolves from novel treatment to everyday practice. So much of how we choose to live our life now was determined by past evidence. But with the volume of information out there, it’s difficult to sift out the […]

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INTERACT2 – A Large Scale Clinical Trial in Stroke

George Clinical, a leading Asia Pacific CRO, is wholly owned by The George Institute, a world leading medical research institute focused on chronic disease. Our model sees us forming integrated project teams with our scientific thought leaders. The Neurological & Mental Health unit, one of the many divisions within The George Institute, has led many […]

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SAFE, the largest clinical trial in critical care medicine

A randomised controlled double-blind study comparing the effects of saline versus albumin on mortality in 6,997 patients, with up to 30 days of follow-up. Saline vs Albumin Read more about the SAFE trial on The George Institute website This trial was completed under budget and ahead of schedule, with results published in The New England […]

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ADVANCE, the largest clinical trial in diabetes

Action in Diabetes Read more about the ADVANCE trial on The George Institute website A factorial, randomised controlled trial study designed to determine the effects of intensive blood pressure lowering and glucose control on cardiovascular risks among type 2 diabetes patients. Covering both advanced economies in North America and Western Europe and emerging economies in […]

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